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Anacondas: Trail of Blood (2009) (original title Anacondas 4: Trail of Blood)
Spoiler Alert !

Some of these pictures and descriptions may give away plot details that you might not want to know before watching the film.
Anacondas: Trail of Blood Anacondas: Trail of Blood Anacondas: Trail of Blood
Anacondas: Trail of Blood Anacondas: Trail of Blood
Anacondas: Trail of Blood Anacondas: Trail of Blood Anacondas: Trail of Blood
Anacondas: Trail of Blood Anacondas: Trail of Blood Anacondas: Trail of Blood
Anacondas: Trail of Blood Anacondas: Trail of Blood Anacondas: Trail of Blood
Anacondas: Trail of Blood Anacondas: Trail of Blood Anacondas: Trail of Blood
"Bigger, Faster, Hungrier"

This made-for-TV movie is the fourth in the Anaconda franchise, which began with Anaconda (1997) which takes place in South America. The second movie, Anacondas: The Hunt for the Blood Orchid (2004), was an attempt to capitalize on the popularity of Anaconda and has nothing to do with the original except the title. None of the cast returns. The action was moved to Borneo where we are introduced to the Blood Orchid, a flower that blooms once every seven years which can prolong life, and which has made the Anacondas in the area bigger, faster, and much more powerful, and these gigantic monster snakes make hunting for the orchid extremely dangerous. The third movie in the franchise, Anaconda 3: Offspring (2008) again had no connections with the second movie, except for the Wexel Hall pharmaceutical company, that sponsored the expedition to find the Blood Orchids in Borneo. The action was moved to Romania in that movie. But this fourth movie is an actual sequel to the third one. (They were filmed at the same time, too.) Many of the characters in the previous movie ended up as snake food, but two of the main characters and several other characters appear again in this sequel, which takes place near the same location in Romania. So far, there is one more film in the franchise, Lake Placid vs. Anaconda (2015), which is a loose sequel to the Lake Placid giant crocodile franchise, with giant Anacondas. They are really getting desperate now. I expect to see Lake Placid vs. Anaconda vs. Boa vs. Python vs. Sharknado any day now.

In the last movie, Anaconda 3, Dr. Amanda Hayes helped to create mutant monster Anacondas in a laboratory using a serum made from Blood Orchids that only works on snakes, not humans. She worked for Murdoch, the ultra-rich CEO of Wexel Hall Pharmaceuticals who needs the serum to cure his cancer or he will die in a week. This movie picks up right where the last one ended, with Murdoch still having only one week to live.

One of Murdoch's employees has been working in another secret laboratory creating a new hybrid of the Blood Orchid. We see that he also has a large snake in a glass cage that he has been using as a serum test subject. (Probably the baby snake that was captured in the last movie.) We learn that the snake has grown five times larger than normal, with side effects that include aggressive behavior that requires constant feeding to maintain its higher metabolic rate. And worse - when it is wounded, it will regenerate. We see the injured snake growing a new head. When it's cut in half, it grows into two monster snakes. And craziest of all, the snake can outcrawl a speeding vehicle, but it can't catch up with people who are running away from it. Strange how that works.

Movie monsters created in a lab usually escape and kill their maker, and that's what happens here. But Murdoch doesn't know that. He thinks his serum scientist disappeared. Murdoch pays a mercenary hunter a million dollars to find the man, the serum he has developed, and his notes. A team of mercenaries drives to the location of his lab. A group of archeologists are also in the area looking for their colleagues at a nearby dig. And a college student out for a hike wanders into the area and runs into Dr. Amanda, who has returned with a couple of police officers to try to atone for her part in creating the killer snakes. That's plenty of snake food to get the movie started, and the body count starts to grow. The snake starts eating people, and it starts growing - to 100 times it's normal size.

As the gore piles up, Amanda finds the serum and the notes. Eventually it appears that the hybrid Blood Orchids and the giant Anaconda are destroyed, but Amanda stupidly (how could she!) threw a backpack containing the serum and notes out of their truck, and we also see that there is a second Anaconda crawling around. That means another sequel was planned, but, as of 2019, it has not been made. (The next movie in the franchise takes place in Maine.)

Once again I'm going to spoil your day by informing you that the giant Anacondas in this movie are not real snakes - they're bad computer-generated images. So no, you can't have one for a pet. These movie Anacondas make the same unbelievable monster sounds they made in the previous movie, and we see the same snake-eye view that we saw in that one, with the picture distorted and off-color. There are also a couple of real snakes in the movie. We see a Boa Constrictor in a cage in a lab, and a shot of a python.