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Lizards in Movies
The Puffy Chair (2005)
Spoiler Alert !

Some of these pictures and descriptions may give away plot details that you might not want to know before watching the film.
The Puffy Chair The Puffy Chair  
Josh and his girlfriend drives cross-country delivering a giant purple reclining chair to his father for his birthday. On the way, he stops to see his brother Rhett, who lives outside Philadelphia to invite him along. When they get to Rhett's place they find him sitting among some plants in a parking lot with a video camera. Inside he shows the couple that he has been videotaping Green Anoles.

This comes up a couple of times in the movie, with the implication that it shows that Rhett is misguided because he sits around all day doing something stupid and wasteful.

As a misguided guy who has sat around taking pictures and video of lizards, I got a good laugh at that.

According to IMDB, Rhett is based on the actor who plays him, and the lizard video we see was actually shot by the actor before the movie was made.